Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β. [electronic resource]
Producer: 20130206Description: 1236-49 p. digitalISSN:- 1525-2191
- Animals
- Antigens, Neoplasm -- metabolism
- Cell Nucleus -- drug effects
- Connective Tissue Growth Factor -- genetics
- Cytokines -- genetics
- Fibrosis
- GTP-Binding Protein alpha Subunits, Gq-G11 -- metabolism
- Gene Expression Regulation -- drug effects
- Humans
- Integrins -- metabolism
- Kidney Tubules, Proximal -- drug effects
- Lipids -- blood
- Lysophospholipids -- pharmacology
- Male
- Mice
- Proto-Oncogene Proteins c-sis -- genetics
- RNA, Messenger -- genetics
- Rats
- Rats, Sprague-Dawley
- Receptors, Lysophosphatidic Acid -- metabolism
- Regeneration -- drug effects
- Reperfusion Injury -- metabolism
- Signal Transduction -- drug effects
- Smad2 Protein -- metabolism
- Time Factors
- Transforming Growth Factor beta -- metabolism
- rho GTP-Binding Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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