BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. [electronic resource]
Producer: 20130417Description: 2029-39 p. digitalISSN:- 1476-5403
- Adaptor Proteins, Signal Transducing -- genetics
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Bcl-2-Like Protein 11
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- drug effects
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Histone Deacetylases -- chemistry
- Humans
- Hydroxamic Acids -- pharmacology
- Indoles -- toxicity
- Melanoma -- metabolism
- Membrane Proteins -- genetics
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins B-raf -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- S Phase Cell Cycle Checkpoints -- drug effects
- Sulfonamides -- toxicity
- Up-Regulation
- Vemurafenib
- Vorinostat
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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