Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. [electronic resource]
Producer: 20121228Description: 5181-7 p. digitalISSN:- 1464-3391
- Adenosine -- analogs & derivatives
- Biomimetic Materials -- chemical synthesis
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- chemical synthesis
- Escherichia coli -- enzymology
- Humans
- Ions -- chemical synthesis
- Molecular Conformation
- N-Glycosyl Hydrolases -- antagonists & inhibitors
- Neisseria meningitidis -- enzymology
- Purine-Nucleoside Phosphorylase -- antagonists & inhibitors
- Pyrrolidines -- chemical synthesis
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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