Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death. [electronic resource]
Producer: 20121205Description: 3030-6 p. digitalISSN:- 1873-3468
- Amino Acid Substitution
- Base Sequence
- Cell Death -- genetics
- DNA Primers -- genetics
- DNA-Binding Proteins -- chemistry
- HEK293 Cells
- Humans
- Huntingtin Protein
- Huntington Disease -- genetics
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutant Proteins -- chemistry
- Nerve Tissue Proteins -- chemistry
- Protein Multimerization
- Protein Stability
- Protein Structure, Tertiary
- Recombinant Proteins -- chemistry
- Transfection
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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