Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension. [electronic resource]
Producer: 20120823Description: 547-52 p. digitalISSN:- 0031-7144
- Actins -- biosynthesis
- Animals
- Arterioles -- pathology
- Blood Vessels -- drug effects
- Cell Proliferation -- drug effects
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Hypertension, Pulmonary -- chemically induced
- Immunochemistry
- Immunohistochemistry
- KATP Channels -- agonists
- Male
- Matrix Metalloproteinase 2 -- biosynthesis
- Matrix Metalloproteinase 9 -- biosynthesis
- Monocrotaline
- Muscle, Smooth, Vascular -- drug effects
- Myocytes, Smooth Muscle -- drug effects
- Pinacidil -- pharmacology
- Poisons
- Polymerase Chain Reaction
- Pulmonary Circulation -- drug effects
- Rats
- Simvastatin -- pharmacology
- Tissue Inhibitor of Metalloproteinase-1 -- metabolism
- Transforming Growth Factor beta -- biosynthesis
- Vasodilator Agents -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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