Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. [electronic resource]
Producer: 20121126Description: 7114-40 p. digitalISSN:- 1520-4804
- Animals
- Benzamides -- chemical synthesis
- Biological Availability
- Blood Platelets -- cytology
- Cell Line
- Cell Membrane Permeability
- Cell Size
- Cytochrome P-450 Enzyme Inhibitors
- Dogs
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels -- antagonists & inhibitors
- Guanidines -- chemical synthesis
- Humans
- Male
- Membranes, Artificial
- Microsomes, Liver -- metabolism
- Models, Molecular
- Myocardial Infarction -- drug therapy
- Myocardial Reperfusion Injury -- prevention & control
- Permeability
- Protein Isoforms -- antagonists & inhibitors
- Rats
- Rats, Sprague-Dawley
- Sodium-Hydrogen Exchanger 1
- Sodium-Hydrogen Exchangers -- antagonists & inhibitors
- Structure-Activity Relationship
No physical items for this record
Publication Type: Journal Article
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