c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin-ATP-binding cassette G2 signaling. [electronic resource]
Producer: 20130729Description: 2767-81 p. digitalISSN:- 1476-5594
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters -- metabolism
- Animals
- Antineoplastic Agents -- pharmacology
- Benzamides -- pharmacology
- Cell Hypoxia
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Cell Transformation, Neoplastic -- genetics
- Cisplatin -- pharmacology
- Drug Resistance, Neoplasm -- genetics
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Imatinib Mesylate
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Proteins -- metabolism
- Neoplastic Stem Cells -- drug effects
- Ovarian Neoplasms -- drug therapy
- Paclitaxel -- pharmacology
- Piperazines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-kit -- genetics
- Pyrimidines -- pharmacology
- RNA Interference
- RNA, Small Interfering
- Tumor Microenvironment
- Wnt Proteins -- metabolism
- Wnt Signaling Pathway -- drug effects
- Xenograft Model Antitumor Assays
- beta Catenin -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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