Development of an SPE-LC-MS/MS method for simultaneous quantification of bosentan and its active metabolite hydroxybosentan in human plasma to support a bioequivalence study. [electronic resource]
Producer: 20130207Description: 462-70 p. digitalISSN:- 1873-264X
- Administration, Oral
- Adult
- Antihypertensive Agents -- administration & dosage
- Area Under Curve
- Biotransformation
- Bosentan
- Calibration
- Chromatography, High Pressure Liquid -- standards
- Chromatography, Reverse-Phase -- standards
- Cross-Over Studies
- Fasting -- blood
- Half-Life
- Humans
- Hydroxylation
- India
- Male
- Metabolic Clearance Rate
- Reference Standards
- Reproducibility of Results
- Sensitivity and Specificity
- Solid Phase Extraction -- standards
- Sulfonamides -- administration & dosage
- Tablets
- Tandem Mass Spectrometry -- standards
- Therapeutic Equivalency
- Young Adult
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Publication Type: Journal Article; Randomized Controlled Trial
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