Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. [electronic resource]
Producer: 20121105Description: 6784-801 p. digitalISSN:- 1520-4804
- Alzheimer Disease -- drug therapy
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Avoidance Learning -- drug effects
- Biological Availability
- Brain -- metabolism
- Click Chemistry
- Cognition Disorders -- drug therapy
- Glucose -- deficiency
- Hippocampus -- drug effects
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Mimicry
- Mutation
- Neurons -- cytology
- Neuroprotective Agents -- chemical synthesis
- Nitric Oxide -- chemistry
- Oxygen -- metabolism
- Primary Cell Culture
- Prodrugs -- chemical synthesis
- Receptors, GABA-A -- metabolism
- Small Molecule Libraries
- Structure-Activity Relationship
- Synaptic Transmission -- drug effects
- Thiazoles -- chemical synthesis
- Tissue Distribution
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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