Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation. [electronic resource]
Producer: 20130123Description: 910-8 p. digitalISSN:- 1791-2423
- Acetylcysteine -- pharmacology
- Apoptosis -- drug effects
- Azacitidine -- analogs & derivatives
- Baculoviral IAP Repeat-Containing 3 Protein
- Caspases -- metabolism
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Decitabine
- Down-Regulation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Humans
- Inhibitor of Apoptosis Proteins -- biosynthesis
- Leukemia -- drug therapy
- Membrane Potential, Mitochondrial -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Reactive Oxygen Species -- metabolism
- Ubiquitin-Protein Ligases
- X-Linked Inhibitor of Apoptosis Protein -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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