Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. [electronic resource]
Producer: 20130124Description: 858-66 p. digitalISSN:- 1099-1263
- Artificial Intelligence
- Calcium Channel Blockers -- adverse effects
- Calcium Channels, L-Type -- chemistry
- Cell Line
- Computational Biology
- Computer Simulation
- Drugs, Investigational -- adverse effects
- Ether-A-Go-Go Potassium Channels -- antagonists & inhibitors
- Expert Systems
- Heart Rate -- drug effects
- Humans
- Models, Biological
- Myocytes, Cardiac -- drug effects
- NAV1.5 Voltage-Gated Sodium Channel -- chemistry
- Potassium Channel Blockers -- adverse effects
- Quantitative Structure-Activity Relationship
- Risk Assessment -- methods
- Shaker Superfamily of Potassium Channels -- antagonists & inhibitors
- Torsades de Pointes -- chemically induced
- Voltage-Gated Sodium Channel Blockers -- adverse effects
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Study
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