DAT-230, a novel microtubule inhibitor, exhibits potent anti-tumor activity by inducing G2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080. [electronic resource]
Producer: 20121019Description: 259-70 p. digitalISSN:- 1432-0843
- Aniline Compounds -- chemistry
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Cell Line, Tumor
- Cell Survival -- drug effects
- Fibrosarcoma -- blood supply
- Flow Cytometry
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Microscopy, Fluorescence
- Molecular Structure
- Nitric Oxide -- biosynthesis
- Reactive Oxygen Species -- metabolism
- Thiophenes -- chemistry
- Tubulin Modulators -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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