MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.). [electronic resource]
Producer: 20130619Description: 2239-46 p. digitalISSN:- 1476-5594
- Antineoplastic Agents -- pharmacology
- Benzamides -- pharmacology
- Cell Differentiation
- Cell Line, Tumor
- Cell Proliferation
- Cyclin-Dependent Kinase Inhibitor p27 -- genetics
- Dasatinib
- Down-Regulation
- Erythroid Cells -- drug effects
- Gene Expression
- Gene Expression Regulation, Leukemic
- Humans
- Imatinib Mesylate
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Piperazines -- pharmacology
- Proto-Oncogene Proteins c-myc -- physiology
- Pyrimidines -- pharmacology
- S-Phase Kinase-Associated Proteins -- metabolism
- Thiazoles -- pharmacology
- beta-Globins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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