Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. [electronic resource]
Producer: 20120913Description: 959-73 p. digitalISSN:- 1097-4180
- Animals
- Cell-Free System
- DEAD Box Protein 58
- DEAD-box RNA Helicases -- chemistry
- Encephalomyocarditis virus -- genetics
- Fibroblasts -- metabolism
- HEK293 Cells -- metabolism
- Humans
- Interferon Regulatory Factor-3 -- metabolism
- Interferon-Induced Helicase, IFIH1
- Interferon-beta -- biosynthesis
- Mice
- Multiprotein Complexes
- Mutagenesis, Site-Directed
- Polyubiquitin -- metabolism
- Protein Binding
- Protein Interaction Mapping
- Protein Processing, Post-Translational
- Protein Structure, Tertiary
- RNA, Viral -- metabolism
- Receptors, Immunologic
- Recombinant Fusion Proteins -- chemistry
- Signal Transduction -- physiology
- Structure-Activity Relationship
- Ubiquitination
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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