B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin. [electronic resource]
Producer: 20130522Description: R145 p. digitalISSN:- 1478-6362
- Adult
- Antibodies, Monoclonal, Murine-Derived -- therapeutic use
- Antirheumatic Agents -- therapeutic use
- B-Lymphocytes -- drug effects
- Female
- Fibrosis
- Humans
- Immunohistochemistry
- Lymphocyte Depletion -- methods
- Male
- Middle Aged
- Receptor, Platelet-Derived Growth Factor alpha -- biosynthesis
- Receptor, Platelet-Derived Growth Factor beta -- biosynthesis
- Receptors, Platelet-Derived Growth Factor -- metabolism
- Rituximab
- Scleroderma, Diffuse -- drug therapy
- Skin -- metabolism
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Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
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