Correction of murine Rag2 severe combined immunodeficiency by lentiviral gene therapy using a codon-optimized RAG2 therapeutic transgene. [electronic resource]
Producer: 20130328Description: 1968-80 p. digitalISSN:- 1525-0024
- Animals
- B-Lymphocytes -- metabolism
- Cell Proliferation
- Chimerism
- Chromatin
- Codon -- genetics
- DNA-Binding Proteins -- genetics
- Female
- Gene Dosage
- Gene Rearrangement
- Genes, T-Cell Receptor beta
- Genetic Therapy -- methods
- Genetic Vectors -- genetics
- Hematopoietic Stem Cells -- metabolism
- Lentivirus -- genetics
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Mice, SCID
- Phenotype
- Plasmids
- Promoter Regions, Genetic
- Sequence Analysis, DNA
- Severe Combined Immunodeficiency -- genetics
- Spleen -- cytology
- Spleen Focus-Forming Viruses -- genetics
- T-Lymphocytes -- metabolism
- Transduction, Genetic
- Transgenes
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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