Water extract of Hedyotis Diffusa Willd suppresses proliferation of human HepG2 cells and potentiates the anticancer efficacy of low-dose 5-fluorouracil by inhibiting the CDK2-E2F1 pathway. [electronic resource]
Producer: 20130124Description: 742-8 p. digitalISSN:- 1791-2431
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Carcinoma, Hepatocellular -- drug therapy
- Cell Growth Processes -- drug effects
- Cell Line, Tumor
- Cyclin-Dependent Kinase 2 -- antagonists & inhibitors
- Dose-Response Relationship, Drug
- Drug Synergism
- E2F1 Transcription Factor -- antagonists & inhibitors
- Female
- Fluorouracil -- administration & dosage
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Hedyotis -- chemistry
- Hep G2 Cells
- Humans
- Liver Neoplasms -- drug therapy
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Plant Extracts -- administration & dosage
- RNA, Messenger -- biosynthesis
- Resting Phase, Cell Cycle -- drug effects
- S Phase -- drug effects
- Water -- chemistry
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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