Dihydrotestosterone ameliorates degeneration in muscle, axons and motoneurons and improves motor function in amyotrophic lateral sclerosis model mice. [electronic resource]
Producer: 20121016Description: e37258 p. digitalISSN:- 1932-6203
- Amyotrophic Lateral Sclerosis -- drug therapy
- Androgens -- metabolism
- Animals
- Axons -- drug effects
- Body Weight -- drug effects
- Dihydrotestosterone -- therapeutic use
- Disease Models, Animal
- Gene Expression -- drug effects
- Humans
- Insulin-Like Growth Factor I -- genetics
- Insulin-Like Growth Factor II -- genetics
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Motor Neurons -- drug effects
- Motor Skills -- drug effects
- Muscle Proteins -- genetics
- Muscle Strength -- drug effects
- Muscle, Skeletal -- drug effects
- Muscular Atrophy -- drug therapy
- Neuromuscular Junction -- drug effects
- Neuroprotective Agents -- therapeutic use
- Superoxide Dismutase -- genetics
- Tripartite Motif Proteins
- Ubiquitin-Protein Ligases -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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