Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells. [electronic resource]
Producer: 20121205Description: 445-58 p. digitalISSN:- 1521-2254
- Animals
- Apoptosis
- Cell Line, Tumor
- Cell Survival
- Chemotherapy, Adjuvant
- Cytosine Deaminase -- genetics
- Drug Resistance, Neoplasm
- Drug Therapy, Combination
- Escherichia coli -- enzymology
- Flucytosine -- therapeutic use
- Genes, Transgenic, Suicide -- genetics
- Genetic Therapy -- methods
- Humans
- Lung Neoplasms -- therapy
- Male
- Mice
- Nitroreductases -- therapeutic use
- Pentosyltransferases -- genetics
- Promoter Regions, Genetic -- genetics
- Repressor Proteins -- genetics
- Small Cell Lung Carcinoma -- therapy
- Yeasts -- enzymology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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