Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. [electronic resource]
Producer: 20120917Description: 1818-26 p. digitalISSN:- 1551-4005
- Camptothecin -- analogs & derivatives
- Cell Cycle Checkpoints
- Checkpoint Kinase 1
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- DNA Damage
- Gene Expression Regulation, Neoplastic
- HCT116 Cells
- Half-Life
- Humans
- Irinotecan
- Kinetics
- Phosphorylation
- Polyribosomes -- metabolism
- Protein Biosynthesis
- Protein Kinases -- genetics
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- RNA, Messenger -- genetics
- RNA, Neoplasm -- genetics
- Signal Transduction
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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