The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium. [electronic resource]
Producer: 20120820Description: e34468 p. digitalISSN:- 1932-6203
- 8-Hydroxy-2-(di-n-propylamino)tetralin -- pharmacology
- Aged
- Aged, 80 and over
- Animals
- Antioxidants -- metabolism
- Cell Line
- Cytoprotection -- drug effects
- Humans
- Lipofuscin -- metabolism
- Macular Degeneration -- metabolism
- Mice
- Middle Aged
- Mitochondria -- drug effects
- Oxidative Stress -- drug effects
- Receptors, Serotonin -- metabolism
- Retinal Pigment Epithelium -- cytology
- Serotonin Receptor Agonists -- pharmacology
- Superoxides -- metabolism
- Vision, Ocular -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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