Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice. [electronic resource]
Producer: 20120730Description: 5294-300 p. digitalISSN:- 1528-0020
- Amino Acid Substitution
- Animals
- Antibodies, Neutralizing -- immunology
- Autoantibodies -- immunology
- Blood Coagulation Factor Inhibitors -- immunology
- CD4-Positive T-Lymphocytes -- immunology
- Dendritic Cells -- immunology
- Disease Models, Animal
- Factor VIII -- genetics
- Hemophilia A -- drug therapy
- Humans
- Macrophages -- immunology
- Mice
- Mice, Knockout
- Monocytes -- immunology
- Mutation, Missense
- Protein Structure, Tertiary
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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