Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo. [electronic resource]
Producer: 20120713Description: 1477-87 p. digitalISSN:- 1524-4636
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antibodies -- pharmacology
- Blood Coagulation
- CD40 Antigens -- antagonists & inhibitors
- CD40 Ligand -- antagonists & inhibitors
- Case-Control Studies
- Cell-Derived Microparticles -- enzymology
- Cells, Cultured
- Disease Models, Animal
- Disseminated Intravascular Coagulation -- enzymology
- Endothelial Cells -- drug effects
- Endotoxemia -- enzymology
- Female
- Gene Expression Regulation, Enzymologic
- Hirudins -- pharmacology
- Human Umbilical Vein Endothelial Cells -- enzymology
- Humans
- Lipopolysaccharides -- pharmacology
- Male
- Matrix Metalloproteinase 10 -- blood
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Middle Aged
- Mitogen-Activated Protein Kinase 8 -- antagonists & inhibitors
- Multivariate Analysis
- Peptides -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- RNA, Messenger -- metabolism
- Receptor, PAR-1 -- agonists
- Risk Assessment
- Risk Factors
- Sepsis -- enzymology
- Signal Transduction
- Spain
- Survival Analysis
- Thrombin -- metabolism
- Time Factors
- Up-Regulation
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Platelet Aggregation Inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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