Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma. [electronic resource]
Producer: 20130408Description: 1221-9 p. digitalISSN:- 1349-7006
- Arecoline -- pharmacology
- Blotting, Western
- Carcinoma, Squamous Cell -- genetics
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cholinergic Agonists -- pharmacology
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- Cyclin-Dependent Kinase Inhibitor p27 -- genetics
- DNA Damage
- Down-Regulation -- drug effects
- G1 Phase Cell Cycle Checkpoints -- drug effects
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Male
- Mechanistic Target of Rapamycin Complex 1
- Microscopy, Fluorescence
- Mouth Neoplasms -- genetics
- Multiprotein Complexes -- genetics
- Reactive Oxygen Species -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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