Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. [electronic resource]
Producer: 19900628Description: 153-60 p. digitalISSN:- 0264-6021
- Adenosine Diphosphate -- pharmacology
- Amino Acid Isomerases -- antagonists & inhibitors
- Animals
- Bongkrekic Acid -- pharmacology
- Calcium -- pharmacology
- Cell Membrane Permeability
- Cyclosporins -- metabolism
- Kinetics
- Light
- Mitochondria, Heart -- drug effects
- Mitochondria, Liver -- drug effects
- Mitochondrial ADP, ATP Translocases -- antagonists & inhibitors
- Mitochondrial Swelling -- drug effects
- Nucleotidyltransferases -- metabolism
- Peptidylprolyl Isomerase
- Rats
- Scattering, Radiation
- Sucrose
- Thiocyanates
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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