Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. [electronic resource]
Producer: 20120921Description: 308-32 p. digitalISSN:- 1873-7544
- Animals
- Apoptosis -- drug effects
- Central Nervous System Stimulants -- toxicity
- DNA Fragmentation
- Dopaminergic Neurons -- drug effects
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Methamphetamine -- toxicity
- Microscopy, Electron, Transmission
- Nerve Degeneration -- chemically induced
- Proteasome Endopeptidase Complex
- Protein Kinase C-delta -- metabolism
- RNA, Small Interfering
- Rats
- Rats, Wistar
- Signal Transduction -- drug effects
- Transfection
- Ubiquitin-Protein Ligase Complexes -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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