Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation. [electronic resource]
Producer: 20130104Description: 1374-82 p. digitalISSN:- 1551-4005
- Carcinoma, Squamous Cell -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin D1 -- metabolism
- Cyclin E -- analysis
- Cyclin-Dependent Kinase 2 -- metabolism
- Cyclin-Dependent Kinase 4 -- metabolism
- Cyclin-Dependent Kinase 6 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p15 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p18 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Head and Neck Neoplasms -- drug therapy
- Humans
- Metformin -- pharmacology
- Neoplasm Proteins -- metabolism
- Protein Biosynthesis -- drug effects
- S-Phase Kinase-Associated Proteins -- metabolism
- Squamous Cell Carcinoma of Head and Neck
- beta-Transducin Repeat-Containing Proteins -- metabolism
- rho GTP-Binding Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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