First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. [electronic resource]
Producer: 20120831Description: 3488-501 p. digitalISSN:- 1520-4804
- Adrenergic Uptake Inhibitors -- chemical synthesis
- Analgesics -- chemical synthesis
- Animals
- CHO Cells
- Coronary Vessels -- drug effects
- Cricetinae
- Cricetulus
- Cyclohexanes -- chemical synthesis
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels -- antagonists & inhibitors
- HEK293 Cells
- High-Throughput Screening Assays
- Humans
- In Vitro Techniques
- Indoles -- chemical synthesis
- Muscle Contraction
- Muscle, Smooth, Vascular -- drug effects
- Neuralgia -- drug therapy
- Nitric Oxide Synthase Type I -- antagonists & inhibitors
- Norepinephrine Plasma Membrane Transport Proteins -- metabolism
- Rats
- Stereoisomerism
- Structure-Activity Relationship
- Thiophenes -- chemical synthesis
- Vascular Resistance
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Publication Type: Journal Article
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