Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo. [electronic resource]
Producer: 20130218Description: 1122-32 p. digitalISSN:- 1538-8514
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- administration & dosage
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Bcl-2-Like Protein 11
- Cell Line, Tumor
- Drug Synergism
- Germinal Center -- drug effects
- Histones -- metabolism
- Humans
- Indoles
- Lymphoma, Large B-Cell, Diffuse -- drug therapy
- MAP Kinase Kinase 4 -- metabolism
- Membrane Proteins -- metabolism
- Mice
- Mice, Nude
- Myeloid Cell Leukemia Sequence 1 Protein
- Oligopeptides -- administration & dosage
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors
- Protein Binding
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Pyrroles -- administration & dosage
- Xenograft Model Antitumor Assays
- bcl-2 Homologous Antagonist-Killer Protein -- metabolism
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication
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