Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers. [electronic resource]
Producer: 20120716Description: 654-67 p. digitalISSN:- 1879-114X
- Administration, Oral
- Adolescent
- Adult
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Peptides -- blood
- Basic Helix-Loop-Helix Transcription Factors -- blood
- Biomarkers -- analysis
- Dose-Response Relationship, Drug
- Dual Specificity Phosphatase 6 -- blood
- Homeodomain Proteins -- blood
- Humans
- Male
- Oxadiazoles -- administration & dosage
- Peptide Fragments -- blood
- Peptides -- blood
- Sulfonamides -- administration & dosage
- Transcription Factor HES-1
- Trefoil Factor-3
- Young Adult
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Publication Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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