Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity. [electronic resource]
Producer: 20120720Description: 41-8 p. digitalISSN:- 1873-7544
- Animals
- Blotting, Western
- Cells, Cultured
- Chemokines -- metabolism
- Culture Media, Conditioned
- Cytokines -- biosynthesis
- Electrophoresis, Polyacrylamide Gel
- Gene Expression Profiling
- Humans
- Immunohistochemistry
- Inflammation -- genetics
- Interferon-gamma -- pharmacology
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lipopolysaccharides -- pharmacology
- Macrophage Activation -- physiology
- Mice
- Mice, Transgenic
- Microglia -- metabolism
- Mutation -- physiology
- Neurons -- physiology
- Neurotoxicity Syndromes -- genetics
- Parkinson Disease -- genetics
- Protein Serine-Threonine Kinases -- genetics
- Signal Transduction -- drug effects
- Toll-Like Receptor 4 -- biosynthesis
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Publication Type: Journal Article
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