Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways. [electronic resource]
Producer: 20121108Description: 2175-86 p. digitalISSN:- 1097-0215
- Animals
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Cell Line, Tumor -- drug effects
- Cell Proliferation -- drug effects
- Cyclin D1 -- antagonists & inhibitors
- ErbB Receptors -- metabolism
- Humans
- Inhibitor of Apoptosis Proteins -- antagonists & inhibitors
- Male
- Matrix Metalloproteinase Inhibitors
- Mice
- Mice, SCID
- NF-kappa B -- metabolism
- Naphthoquinones -- pharmacology
- Pancreatic Neoplasms -- drug therapy
- Phosphorylation
- Plant Extracts -- pharmacology
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Survivin
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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