4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity. [electronic resource]
Producer: 20120814Description: 484-95 p. digitalISSN:- 1878-5867
- Animals
- Binding Sites
- CD4-Positive T-Lymphocytes -- drug effects
- Cholesterol -- analogs & derivatives
- Cytokines -- genetics
- Gene Expression -- drug effects
- Gene Expression Profiling
- Hep G2 Cells
- Humans
- Isomerism
- Liver -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Models, Molecular
- Molecular Structure
- Monocytes -- drug effects
- Pregnane X Receptor
- Protein Binding
- Protein Structure, Tertiary
- Receptors, Cytoplasmic and Nuclear -- antagonists & inhibitors
- Receptors, Steroid -- agonists
- Reverse Transcriptase Polymerase Chain Reaction
- Sterols -- chemistry
- T-Lymphocytes, Regulatory -- drug effects
- Theonella -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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