MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition. [electronic resource]
Producer: 20121213Description: 4434-46 p. digitalISSN:- 1476-5594
- Antibodies, Monoclonal, Humanized -- pharmacology
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Base Sequence
- Breast Neoplasms -- drug therapy
- Cell Line, Tumor
- Chromatin Immunoprecipitation
- Drug Resistance, Neoplasm -- genetics
- Female
- Gene Expression Regulation, Neoplastic
- Gene Knockdown Techniques
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Phosphorylation
- Protein Array Analysis
- Protein Processing, Post-Translational
- Protein Serine-Threonine Kinases -- genetics
- Pteridines -- pharmacology
- Ribosomal Protein S6 Kinases, 90-kDa -- antagonists & inhibitors
- Sequence Analysis, DNA
- Transcription, Genetic
- Trastuzumab
- Y-Box-Binding Protein 1 -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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