Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor. [electronic resource]
Producer: 20120514Description: e28899 p. digitalISSN:- 1932-6203
- Adenine -- analogs & derivatives
- Animals
- Cyclic AMP -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 4 -- chemistry
- Disease Progression
- Female
- Humans
- Isoenzymes
- Kidney -- cytology
- Lipopolysaccharides -- pharmacology
- Lupus Erythematosus, Systemic -- drug therapy
- Mice
- Mice, Inbred CBA
- Mice, Inbred MRL lpr
- Pentoxifylline -- therapeutic use
- Phosphodiesterase 4 Inhibitors -- therapeutic use
- Proteinuria -- drug therapy
- Survival Rate
- Tumor Necrosis Factor-alpha -- metabolism
- Xanthines -- therapeutic use
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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