Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B. [electronic resource]
Producer: 20120330Description: 192-200 p. digitalISSN:- 1476-4679
- Adaptor Proteins, Vesicular Transport -- deficiency
- Animals
- Cells, Cultured
- Embryo, Mammalian -- cytology
- Endoplasmic Reticulum Stress -- drug effects
- Eukaryotic Initiation Factor-2B -- genetics
- Fibroblasts -- cytology
- Immunoblotting
- Lipopolysaccharides -- pharmacology
- Macrophages -- cytology
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Phosphorylation -- drug effects
- Protein Biosynthesis -- drug effects
- Protein Phosphatase 2 -- metabolism
- RNA Interference
- Serine -- metabolism
- Signal Transduction -- drug effects
- Toll-Like Receptor 4 -- genetics
- Transcription Factor CHOP -- genetics
- Tunicamycin -- pharmacology
- Unfolded Protein Response -- drug effects
- src-Family Kinases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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