Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. [electronic resource]
Producer: 20120307Description: 724-31 p. digitalISSN:- 1520-4995
- Antineoplastic Agents -- pharmacology
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors -- chemistry
- Basic Helix-Loop-Helix Transcription Factors -- metabolism
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Crystallography, X-Ray
- Down-Regulation -- drug effects
- Drug Evaluation, Preclinical -- methods
- HCT116 Cells
- Humans
- Models, Molecular
- Protein Binding -- drug effects
- Protein Conformation
- Small Molecule Libraries -- pharmacology
- Transcription Factor 4
- Transcription Factors -- chemistry
- Transcription, Genetic -- drug effects
- User-Computer Interface
- Wnt Signaling Pathway -- drug effects
- beta Catenin -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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