IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [electronic resource]
Producer: 20120827Description: e28663 p. digitalISSN:- 1932-6203
- Animals
- Apoptosis -- drug effects
- Becaplermin
- Cartilage -- drug effects
- Cell Differentiation -- drug effects
- Cells, Cultured
- Chondrocytes -- drug effects
- Collagen Type II -- metabolism
- Dogs
- Down-Regulation -- drug effects
- Enzyme Activation -- drug effects
- Extracellular Matrix -- drug effects
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- I-kappa B Proteins -- metabolism
- Imidazoles -- pharmacology
- Insulin-Like Growth Factor I -- pharmacology
- Integrin beta1 -- metabolism
- Interleukin-1beta -- pharmacology
- NF-KappaB Inhibitor alpha
- NF-kappa B -- metabolism
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-sis -- pharmacology
- Quinoxalines -- pharmacology
- SOX9 Transcription Factor -- metabolism
- Shc Signaling Adaptor Proteins -- metabolism
- Signal Transduction -- drug effects
- src-Family Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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