TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes. [electronic resource]
Producer: 20120918Description: 109-18 p. digitalISSN:- 1551-4005
- Animals
- Cell Cycle Proteins -- genetics
- Cell Line
- Cell Proliferation -- drug effects
- Chromosomal Proteins, Non-Histone -- genetics
- E2F1 Transcription Factor -- antagonists & inhibitors
- Gene Expression Regulation -- drug effects
- Humans
- MAP Kinase Kinase Kinases -- antagonists & inhibitors
- Mitogen-Activated Protein Kinase 8 -- antagonists & inhibitors
- Muscle, Smooth, Vascular -- cytology
- Proto-Oncogene Proteins c-raf
- RNA Interference
- RNA, Small Interfering -- metabolism
- Rats
- Retinoblastoma Protein -- antagonists & inhibitors
- S Phase
- Thiourea -- analogs & derivatives
- Thymidylate Synthase -- genetics
- Tumor Necrosis Factor-alpha -- metabolism
- cdc25 Phosphatases -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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