The antidiabetic drug ciglitazone induces high grade bladder cancer cells apoptosis through the up-regulation of TRAIL. [electronic resource]
Producer: 20120423Description: e28354 p. digitalISSN:- 1932-6203
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- BH3 Interacting Domain Death Agonist Protein -- metabolism
- CASP8 and FADD-Like Apoptosis Regulating Protein -- metabolism
- Caspases -- metabolism
- Cell Line, Tumor
- Cell Membrane -- drug effects
- Enzyme Activation -- drug effects
- G2 Phase -- drug effects
- Humans
- Hypoglycemic Agents -- pharmacology
- Inhibitor of Apoptosis Proteins -- metabolism
- Mice
- Mitosis -- drug effects
- Neoplasm Grading
- PPAR gamma -- metabolism
- Proteasome Endopeptidase Complex -- metabolism
- Receptors, Death Domain -- metabolism
- Signal Transduction -- drug effects
- Survivin
- TNF-Related Apoptosis-Inducing Ligand -- metabolism
- Thiazolidinediones -- pharmacology
- Transcriptional Activation -- drug effects
- Up-Regulation -- drug effects
- Urinary Bladder Neoplasms -- drug therapy
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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