Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex. [electronic resource]
Producer: 20120917Description: 1488-500 p. digitalISSN:- 1097-4644
- Adaptor Proteins, Signal Transducing -- metabolism
- Carrier Proteins -- metabolism
- Cell Line, Tumor
- Chromones -- pharmacology
- Cyclic AMP -- analogs & derivatives
- Cyclic AMP Response Element-Binding Protein -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 3 -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 4
- Endoplasmic Reticulum Chaperone BiP
- Gene Silencing
- Guanine Nucleotide Exchange Factors -- agonists
- Humans
- Male
- Mechanistic Target of Rapamycin Complex 1
- Models, Biological
- Morpholines -- pharmacology
- Multiprotein Complexes -- metabolism
- Phosphorylation
- Prostatic Neoplasms -- genetics
- Protein Multimerization -- drug effects
- Proteins -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- RNA-Binding Proteins -- metabolism
- Rapamycin-Insensitive Companion of mTOR Protein
- Regulatory-Associated Protein of mTOR
- Ribosomal Protein S6 Kinases -- metabolism
- Signal Transduction -- drug effects
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases
- Thionucleotides -- pharmacology
- Up-Regulation -- drug effects
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Publication Type: Journal Article
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