Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells. [electronic resource]
Producer: 20120213Description: 42-55 p. digitalISSN:- 1460-2105
- Animals
- Antineoplastic Agents, Alkylating -- pharmacology
- Ataxia Telangiectasia Mutated Proteins
- Brain Neoplasms -- drug therapy
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Cell Survival
- Chlorocebus aethiops
- DNA Damage
- DNA Modification Methylases -- metabolism
- DNA Repair -- drug effects
- DNA Repair Enzymes -- metabolism
- DNA-Binding Proteins -- genetics
- Dacarbazine -- analogs & derivatives
- Female
- Gene Knockdown Techniques
- Genetic Vectors
- Glioblastoma -- drug therapy
- Humans
- Immunoblotting
- Immunohistochemistry
- Methylation
- Mice
- Mice, Nude
- Neoplastic Stem Cells -- drug effects
- Oncolytic Virotherapy -- methods
- Polymerase Chain Reaction
- Protein Serine-Threonine Kinases -- metabolism
- Simplexvirus -- genetics
- Temozolomide
- Tumor Suppressor Proteins -- metabolism
- Vero Cells
- Virus Replication
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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