WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing. [electronic resource]
Producer: 20120206Description: 768-80 p. digitalISSN:- 1878-3686
- Animals
- Cell Line, Tumor
- Cell Nucleus -- metabolism
- Choroidal Neovascularization -- genetics
- Denys-Drash Syndrome -- genetics
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- Humans
- Luciferases, Renilla -- biosynthesis
- Mice
- Mice, Inbred C57BL
- Mice, Nude
- Neoplasm Transplantation
- Neoplasms -- blood supply
- Neovascularization, Pathologic -- genetics
- Nuclear Proteins -- metabolism
- Podocytes -- metabolism
- Promoter Regions, Genetic
- Protein Binding
- Protein Isoforms -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein Transport
- RNA Interference
- RNA Splicing -- genetics
- RNA-Binding Proteins -- metabolism
- Serine-Arginine Splicing Factors
- Vascular Endothelial Growth Factor B -- genetics
- Vascular Endothelial Growth Factor Receptor-2 -- metabolism
- WT1 Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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