WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes. [electronic resource]
Producer: 20120419Description: 3967-79 p. digitalISSN:- 1477-9137
- Ataxia Telangiectasia Mutated Proteins
- Camptothecin -- pharmacology
- Cell Cycle Proteins -- genetics
- Cell Line, Tumor
- Checkpoint Kinase 1
- Chromatin -- genetics
- Chromatin Immunoprecipitation
- DNA Damage
- DNA Replication
- DNA, Single-Stranded -- genetics
- Exodeoxyribonucleases -- genetics
- Gene Expression Regulation, Enzymologic
- Gene Knockdown Techniques
- Genomic Instability
- Humans
- Hydroxyurea -- pharmacology
- Phosphorylation
- Protein Kinases -- genetics
- Protein Serine-Threonine Kinases -- genetics
- RNA, Small Interfering -- genetics
- RecQ Helicases -- genetics
- S Phase Cell Cycle Checkpoints
- Topoisomerase I Inhibitors -- pharmacology
- Werner Syndrome Helicase
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Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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