Cyclosporin a, but not FK506, induces osmotic lysis of pancreas zymogen granules, intra-acinar enzyme release, and lysosome instability by activating K+ channel. [electronic resource]
Producer: 20120816Description: 596-604 p. digitalISSN:- 1536-4828
- Acinar Cells -- drug effects
- Amylases -- metabolism
- Animals
- Biomarkers -- metabolism
- Cathepsin B -- metabolism
- Cyclosporine -- adverse effects
- Immunosuppressive Agents -- adverse effects
- Lysosomes -- drug effects
- Male
- Osmosis -- drug effects
- Pancreas -- blood supply
- Pancreas Transplantation
- Pancreatitis, Graft -- etiology
- Permeability -- drug effects
- Potassium Channels -- drug effects
- Rats
- Rats, Wistar
- Reperfusion Injury -- etiology
- Secretory Vesicles -- drug effects
- Tacrolimus -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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