Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by baicalein. [electronic resource]
Producer: 20120501Description: 1965-72 p. digitalISSN:- 1976-3786
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- antagonists & inhibitors
- Animals
- Antineoplastic Agents, Hormonal -- blood
- Biotransformation -- drug effects
- Cell Line
- Cytochrome P-450 CYP3A -- genetics
- Cytochrome P-450 CYP3A Inhibitors
- Dose-Response Relationship, Drug
- Drug Interactions
- Enzyme Inhibitors -- administration & dosage
- Flavanones -- administration & dosage
- Half-Life
- Humans
- Male
- Membrane Transport Modulators -- administration & dosage
- Metabolic Clearance Rate -- drug effects
- Rats
- Rats, Sprague-Dawley
- Recombinant Proteins -- antagonists & inhibitors
- Tamoxifen -- analogs & derivatives
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Publication Type: Journal Article
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