Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia. [electronic resource]
Producer: 20120801Description: 487-98 p. digitalISSN:- 1557-3265
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antineoplastic Agents -- pharmacology
- Biphenyl Compounds -- pharmacology
- CD40 Antigens -- metabolism
- CD40 Ligand -- metabolism
- Coculture Techniques
- Dasatinib
- Drug Resistance, Neoplasm
- Drug Synergism
- Gene Expression
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Lymph Nodes -- pathology
- Mice
- Middle Aged
- Minor Histocompatibility Antigens
- Myeloid Cell Leukemia Sequence 1 Protein
- NF-kappa B -- metabolism
- NIH 3T3 Cells
- Nitrophenols -- pharmacology
- Piperazines -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Pyrimidines -- pharmacology
- Signal Transduction
- Sulfonamides -- pharmacology
- Thiazoles -- pharmacology
- Tumor Cells, Cultured -- drug effects
- Vidarabine -- analogs & derivatives
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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