Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition. [electronic resource]
Producer: 20120313Description: 826-37 p. digitalISSN:- 1528-0020
- Activating Transcription Factor 4 -- genetics
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Blotting, Western
- Boronic Acids -- pharmacology
- Bortezomib
- Cell Line, Tumor
- Cell Proliferation
- Chromatin Immunoprecipitation
- DNA-Binding Proteins -- antagonists & inhibitors
- Endoplasmic Reticulum -- metabolism
- Endoplasmic Reticulum Stress -- drug effects
- Gene Expression Regulation, Neoplastic
- Humans
- Multiple Myeloma -- drug therapy
- Myeloid Cell Leukemia Sequence 1 Protein
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Pyrazines -- pharmacology
- RNA Splicing
- RNA, Messenger -- genetics
- RNA, Small Interfering -- genetics
- Real-Time Polymerase Chain Reaction
- Regulatory Factor X Transcription Factors
- Transcription Factors -- antagonists & inhibitors
- Transcription, Genetic
- Unfolded Protein Response -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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