Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. [electronic resource]
Producer: 20120413Description: 19611-6 p. digitalISSN:- 1091-6490
- Carboxylic Acids -- metabolism
- Cell Hypoxia
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival
- Citrates -- metabolism
- Citric Acid Cycle
- Gas Chromatography-Mass Spectrometry
- Glucose -- metabolism
- Glutamine -- metabolism
- Humans
- Hypoxia-Inducible Factor 1 -- genetics
- Immunoblotting
- Isocitrate Dehydrogenase -- genetics
- Ketoglutaric Acids -- metabolism
- Neoplasms -- genetics
- Oxidation-Reduction
- RNA Interference
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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