Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts. [electronic resource]
Producer: 20120705Description: 927-33 p. digitalISSN:- 1476-5551
- Animals
- Cell Line, Tumor
- Core Binding Factor Alpha 2 Subunit -- genetics
- Gene Silencing
- Humans
- Mice
- Phosphatidylinositol 3-Kinases -- metabolism
- Precursor Cell Lymphoblastic Leukemia-Lymphoma -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-ets -- genetics
- RNA Interference
- Real-Time Polymerase Chain Reaction
- Repressor Proteins -- genetics
- Signal Transduction
- TOR Serine-Threonine Kinases -- metabolism
- Transplantation, Heterologous
- ETS Translocation Variant 6 Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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